施秉银

日期：2023年03月28日

教授简介

施秉银 教授、博士生导师

国家级项目负责人

中华医学会内分泌学分会常委

中国医师协会内分泌代谢专业委员会副会长

享受国务院特殊津贴专家

卫生部有突出贡献中青年专家

陕西省三五人才

现担任西安交通大学第一附属医院Med-X研究院免疫代谢性疾病研究所所长、中国老年医学学会副会长、中华医学会数字医学分会委员、中国医师协会内分泌代谢科医师分会副会长、陕西省医师协会内分泌代谢科医师分会会长，西安交通大学第一附属医院前院长。1983年毕业于北京大学医学部（原北京医科大学），毕业后一直在西安交通大学第一附属医院工作，2009年至2014年任西安交通大学第一附属医院副院长，2014年至2021年任西安交通大学第一附属医院院长。曾先后主持国家科技部重点专项项目、国家十五攻关项目子课题、国家自然科学基金面上项目、其他省部级项目等各级课题40余项。近5年在Nature, Nature medicine等杂志发表论文150余篇，出版专著5部，项目成果已授权多项国家发明专利。先后获陕西省科技进步奖一等奖1项、二等奖1项，陕西省教学成果特等奖2项、二等奖1项，1998年吴介平医学研究奖，2005年中国医师奖， 2011-2012年度卫生部有突出贡献的中青年专家，2013年全国五一劳动奖章， 2017年宝钢优秀教师奖，以及陕西“十年十大影响力”卫生人物榜、“三秦优秀院长”，首届“西安之星”，2019年中国好医生,2020陕西省第六批三秦楷模等荣誉称号。担任《THYROID》、《中华内科杂志》、《中华内分泌代谢杂志》等杂志编委。近二十年来一直致力于甲亢发病机制研究及疫苗研发，在国内首次成功制备鼠甲亢模型，在国际上首次成功制备恒河猴甲亢模型，树鼩甲亢模型，首次成功诱导了对甲亢的免疫耐受，经过近四年的努力、经反复实验研究证明诱导免疫耐受可有效预防甲亢的发病。已制备出预防甲亢的疫苗正在进一步优化之中。该方法的使用有可能颠覆甲亢未来的防治路径。

荣誉和奖励

2020年

全国先进工作者

2005年

 中国最佳医师奖
     2007年 中国首个百名医德模范

2013年

五一劳动奖章

2019年

中国好医生

2020年

全国先进工作者

学术组织任职

中国医师协会内分泌代谢分会

陕西省内科医师内分泌学与代谢学会

中国老年医学会

陕西省内分泌疾病质量控制中心

Thyroid(USA)

中国内分泌学与代谢杂志

中国内科学杂志

中国医学杂志

中国糖尿病慢性病与转化医学杂志

副会长

会长

副会长

主任

评审编辑

评审编辑

评审编辑

评审编辑

评审编辑

研究方向

1. 自身免疫性甲状腺疾病

施秉银教授课题组围绕针对GD（Graves Dieases）甲状腺疾病，开展了深入的发病机制及免疫干预系列研究，主要方向包括：

1) GD及其并发症多品系动物模型的构建，包括国内首个GD小鼠模型，国际首个猕猴和树鼩GD模型。开创了灵长类动物GD研究的先河。

2) 提出首次提出“新生免疫耐受预防GD”的免疫干预新理念，并在包括鼠、恒河猴、树鼩在内的所有动物研究中得到验证；

3) 促甲状腺素受体TSHR表达体系构建及转化，成功克隆TSH受体并分别建立了酵母和昆虫杆状病毒蛋白及CHO细胞表达系统，已建立制备和生产“甲亢疫苗”的体系，使通过疫苗接种预防人类甲亢成为可能。

论文和著作

1. Wang Y, Chen Z, Wang T, Guo H, Liu Y, Dang N, Hu S, Wu L, Zhang C, Ye K, Shi B 2021. A novel CD4+ CTL subtype characterized by chemotaxis and inflammation is involved in the pathogenesis of Graves' orbitopathy. CELL MOL IMMUNOL.

2.  Yang F, Dang S, Lv H, Shi B 2021 Combined treatment with a gastric inhibitory polypeptide receptor antagonist and  a peptidyl peptidase-4 inhibitor improves metabolic abnormalities in diabetic mice. J INT MED RES 49:1220785216.

3.  Guo J, Teng D, Shi X, Li Y, Ba J, Chen B, Du J, He L, Lai X, Li Y, Chi H, Liao E, Liu C, Liu L, Qin G, Qin Y, Quan H, Shi B, Sun H, Tang X, Tong N, Wang G, Zhang JA, Wang Y, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M, Shan Z, Teng W 2020 Exposure to the Chinese Great Famine in Early Life and Thyroid Function and Disorders in Adulthood: A Cross-Sectional Study. THYROID.

4.   Sun H, Wang H, Lian X, Liu C, Shi B, Shi L, Tong N, Wang S, Weng J, Zhao J, Zhang J, Zheng J, Hu X, Tu Y, Yu L, Shan Z, Teng W, Chen L 2020 Association between Urinary Iodine Concentration and Thyroid Nodules in Adults: A Cross-Sectional Study in China. BIOMED RES INT 2020:4138657.

5.   Kobayashi S, Zhao F, Zhang Z, Kobayashi T, Huang Y, Shi B, Wu W, Liang Q 2020 Mitochondrial Fission and Mitophagy Coordinately Restrict High Glucose Toxicity in Cardiomyocytes. FRONT PHYSIOL 11:604069.

6. Tanizaki Y, Bao L, Shi B, Shi YB 2020 A Role of Endogenous Histone Acetyltransferase Steroid Hormone Receptor Coactivator 3 in Thyroid Hormone Signaling During Xenopus Intestinal Metamorphosis. THYROID.

7.   Wang Y, Liu Y, Yang X, Guo H, Lin J, Yang J, He M, Wang J, Liu X, Shi T, Wu L, Zhang C, Ye K, Shi B 2020 Predicting the early risk of ophthalmopathy in Graves' disease patients using TCR repertoire. Clin Transl Med 10:e218.

8.   Wang Y, Rijntjes E, Wu Q, Lv H, Gao C, Shi B, Schomburg L 2020 Selenium deficiency is linearly associated with hypoglycemia in healthy adults. REDOX BIOL 37:101709.

9.   Zhao L, Teng D, Shi X, Li Y, Ba J, Chen B, Du J, He L, Lai X, Li Y, Chi H, Liao E, Liu C, Liu L, Qin G, Qin Y, Quan H, Shi B, Sun H, Tang X, Tong N, Wang G, Zhang JA, Wang Y, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M, Shan Z, Teng W 2020 The Effect of Increased Iodine Intake on Serum Thyrotropin: A Cross-Sectional, Chinese Nationwide Study. THYROID 30:1810-1819.

10.   Liu LY, Shi BY, Zhao FY, Hou P, Liu S, Liu XM, Wu LP 2020 Effect of Dihydrotestosterone on CostimulatoryMolecules in a Mouse Model of Graves' Disease. Chin Med Sci J 35:215-225.

11.   He MQ, Wang JY, Wang Y, Sui J, Zhang M, Ding X, Zhao Y, Chen ZY, Ren XX, Shi BY 2020 High-fat diet-induced adipose tissue expansion occurs prior to insulin resistance in C57BL/6J mice. Chronic Dis Transl Med 6:198-207.

12.   Wu Y, Shi X, Tang X, Li Y, Tong N, Wang G, Zhang JA, Wang Y, Ba J, Chen B, Du J, He L, Lai X, Li Y, Chi H, Liao E, Liu C, Liu L, Qin G, Qin Y, Quan H, Shi B, Sun H, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M,

13.   Teng D, Yang W, Shi X, Li Y, Ba J, Chen B, Du J, He L, Lai X, Li Y, Chi H, Liao E, Liu C, Liu L, Qin G, Qin Y, Quan H, Shi B, Sun H, Tang X, Tong N, Wang G, Zhang JA, Wang Y, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M, Shan Z, Teng W 2020 An Inverse Relationship Between Iodine Intake and Thyroid Antibodies: A National  Cross-Sectional Survey in Mainland China. THYROID 30:1656-1665.

14.   Wei F, Wu Y, Wang Z, Li Y, Wang J, Shao G, Yang Y, Shi B 2020 Diagnostic significance of DNA methylation of PTEN and DAPK in thyroid tumors. Clin Endocrinol (Oxf) 93:187-195.

15.  Bao L, Shi B, Shi YB 2020 Intestinal homeostasis: a communication between life and death. CELL BIOSCI 10:66.

16.   Li Y, Teng D, Shi X, Qin G, Qin Y, Quan H, Shi B, Sun H, Ba J, Chen B, Du J, He L, Lai X, Li Y, Chi H, Liao E, Liu C, Liu L, Tang X, Tong N, Wang G, Zhang JA, Wang Y, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M, Ning G, Mu Y, Zhao J, Teng W, Shan Z 2020 Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria  from the American Diabetes Association: national cross sectional study. BMJ 369:m997.

17. Jin M, Zhang Z, Li Y, Teng D, Shi X, Ba J, Chen B, Du J, He L, Lai X, Teng X, Li Y, Chi H, Liao E, Liu C, Liu L, Qin G, Qin Y, Quan H, Shi B, Sun H, Tang X, Tong N, Wang G, Zhang JA, Wang Y, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M, Ning G, Mu Y, Zhao J, Teng W, Shan Z 2020 U-Shaped Associations Between Urinary Iodine Concentration and the Prevalence of  Metabolic Disorders: A Cross-Sectional Study. THYROID 30:1053-1065.

18.   Wu Y, Shi X, Tang X, Li Y, Tong N, Wang G, Zhang JA, Wang Y, Ba J, Chen B, Du J, He L, Lai X, Li Y, Chi H, Liao E, Liu C, Liu L, Qin G, Qin Y, Quan H, Shi B, Sun H, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M, Teng W, Shan Z 2020 The Correlation Between Metabolic Disorders And Tpoab/Tgab: A Cross-Sectional Population-Based Study. ENDOCR PRACT 26:869-882.

19.   Li Y, Teng D, Ba J, Chen B, Du J, He L, Lai X, Teng X, Shi X, Li Y, Chi H, Liao E, Liu C, Liu L, Qin G, Qin Y, Quan H, Shi B, Sun H, Tang X, Tong N, Wang G, Zhang JA, Wang Y, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M, Ning G, Mu Y, Zhao J, Shan Z, Teng W 2020 Efficacy and Safety of Long-Term Universal Salt Iodization on Thyroid Disorders:  Epidemiological Evidence from 31 Provinces of Mainland China. THYROID 30:568-579.

20.  Zhang J, Gao Y, Li Y, Teng D, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ba J, Chen B, Du J, He L, Lai X, Teng X, Shi X, Li Y, Chi H, Liao E, Liu C, Liu L, Qin G, Qin Y, Quan H, Shi B, Sun H, Tang X, Tong N, Wang G, Zhang JA, Wang Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M, Teng W, Shan Z, Li J 2020 The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey. Front Endocrinol (Lausanne) 11:139.

21.   Lu X, Shi X, Li Y, Chi H, Liao E, Liu C, Liu L, Li Y, Teng D, Teng X, Ba J, Chen B, Du J, He L, Lai X, Qin G, Qin Y, Quan H, Shi B, Sun H, Tang X, Tong N, Wang G, Zhang JA, Wang Y, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M, Shan Z, Teng W 2020 A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland  China. EUR J NUTR 59:3659-3668

22.   He M, Wang Y, Wang J, Sui J, Ding X, Chen Z, Zhang M, Zhao Y, Xie B, Shi B 2020 The potential markers involved in newly diagnosed graves' disease and the development of active graves' orbitopathy. CYTOKINE 127:154998.

23. Shan Z, Chen L, Lian X, Liu C, Shi B, Shi L, Tong N, Wang S, Weng J, Zhao J, Teng X, Yu X, Lai Y, Wang W, Li C, Mao J, Li Y, Fan C, Teng W. Iodine Status and Prevalence of Thyroid Disorders After Introduction of Mandatory Universal Salt Iodization for 16 Years in China: A Cross-Sectional Study in 10 Cities. Thyroid. 2016 Aug;26(8):1125-30. doi: 10.1089/thy.2015.0613

24. Shi J, Yao D, Liu W, Wang N, Lv H, Zhang G, Ji M, Xu L, He N, Shi B, Hou P. Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer. BMC Cancer. 2012 Feb 1;12:50. doi: 10.1186/1471-2407-12-50.

25. Wu Q, Rayman MP, Lv H, Schomburg L, Cui B, Gao C, Chen P, Zhuang G, Zhang Z, Peng X, Li H, Zhao Y, He X, Zeng G, Qin F, Hou P, Shi B. Low Population Selenium Status Is Associated With Increased Prevalence of Thyroid Disease. J Clin Endocrinol Metab. 2015 Nov;100(11):4037-47. doi: 10.1210/jc.2015-2222.

26. Ji M, Guan H, Gao C, Shi B, Hou P. Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC). BMC Cancer. 2011 Apr 20;11:147. doi: 10.1186/1471-2407-11-147.

27. He M, Shi B. Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics. Cell Biosci. 2017;7:54. Published 2017 Oct 25. doi:10.1186/s13578-017-0183-1

28. Yang Q, Wu K, Ji M, Jin W, He N, Shi B, Hou P. Decreased 5-hydroxymethylcytosine (5-hmC) is an independent poor prognostic factor in gastric cancer patients. J Biomed Nanotechnol. 2013 Sep;9(9):1607-16. doi: 10.1166/jbn.2013.1713.

29. Shi J, Yao D, Liu W, Wang N, Lv H, He N, Shi B, Hou P, Ji M. Frequent gene amplification predicts poor prognosis in gastric cancer. Int J Mol Sci. 2012;13(4):4714-26. doi: 10.3390/ijms13044714.

30. Ji M, Zhang Y, Shi B, Hou P. Association of promoter methylation with histologic type and pleural indentation in non-small cell lung cancer (NSCLC). Diagn Pathol. 2011;6:48. Published 2011 Jun 4. doi:10.1186/1746-1596-6-48

31. Wang L, Tian Z, Yang Q, Li H, Guan H, Shi B, Hou P, Ji M. Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway. Oncotarget. 2015 Sep 22;6(28):25917-31. doi: 10.18632/oncotarget.4542.

32. Yang Q, Ji M, Guan H, Shi B, Hou P. Shikonin inhibits thyroid cancer cell growth and invasiveness through targeting major signaling pathways. J Clin Endocrinol Metab. 2013;98(12):E1909‐E1917. doi:10.1210/jc.2013-2583

33. Liu J, Shi B, He S, Yao X, Willcox MD, Zhao Z. Changes to tear cytokines of type 2 diabetic patients with or without retinopathy. Mol Vis. 2010;16:2931‐2938. Published 2010 Dec 31.

34.   Li, Ya; Shi, Bingyin; Li, Sheli. Association between Serum Chemerin Concentrations and Clinical Indices in Obesity or Metabolic Syndrome: A Meta-Analysis.PlosOne.2014Dec3;9:e113915.doi:10.1371/journal.pone.0113915.

35. Fu J, Lv H, Guan H, Ma X, Ji M, He N, Shi B, Hou P. Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway. BMC Cancer. 2013 Oct 8;13:462. doi: 10.1186/1471-2407-13-462.

36. Yao D, Shi J, Shi B, Wang N, Liu W, Zhang G, Ji M, Xu L, He N, Hou P. Quantitative assessment of gene methylation and their impact on clinical outcome in gastric cancer. Clin Chim Acta. 2012 Apr 11;413(7-8):787-94. doi: 10.1016/j.cca.2012.01.013.

37. Gao K, Li G, Qu Y, Wang M, Cui B, Ji M, Shi B, Hou P. TERT promoter mutations and long telomere length predict poor survival and radiotherapy resistance in gliomas. Oncotarget. 2016 Feb 23;7(8):8712-25. doi: 10.18632/oncotarget.6007.

38. Qiang W, Zhao Y, Yang Q, Liu W, Guan H, Lv S, Ji M, Shi B, Hou P. ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a. J Clin Endocrinol Metab. 2014 Jul;99(7):E1163-72. doi: 10.1210/jc.2013-3729.

39. Liu S, Gao A, Zhang B, Zhang Z, Zhao Y, Chen P, Ji M, Hou P, Shi B. Assessment of molecular testing in fine-needle aspiration biopsy samples: an experience in a Chinese population. Exp Mol Pathol. 2014 Oct;97(2):292-7. doi: 10.1016/j.yexmp.2014.08.005.

40. Zhang G, Qu Y, Dang S, Yang Q, Shi B, Hou P. Variable copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in advanced gastric cancer patients. Diagn Pathol. 2013 Oct 21;8:173. doi: 10.1186/1746-1596-8-173.

41. Lv H, Liu R, Fu J, Yang Q, Shi J, Chen P, Ji M, Shi B, Hou P. Epithelial cell-derived periostin functions as a tumor suppressor in gastric cancer through stabilizing p53 and E-cadherin proteins via the Rb/E2F1/p14ARF/Mdm2 signaling pathway. Cell Cycle. 2014;13(18):2962-74. doi: 10.4161/15384101.2014.947203.

42. Zhang B, Liu S, Zhang Z, Wei J, Qu Y, Wu K, Yang Q, Hou P, Shi B. Analysis of BRAF(V600E) mutation and DNA methylation improves the diagnostics of thyroid fine needle aspiration biopsies. Diagn Pathol. 2014 Mar 3;9:45. doi: 10.1186/1746-1596-9-45.

43. Liu Y, Wang R, Zhang L, Li J, Lou K, Shi B. The lipid metabolism gene FTO influences breast cancer cell energy metabolism via the PI3K/AKT signaling pathway. Oncol Lett. 2017 Jun;13(6):4685-4690. doi: 10.3892/ol.2017.6038.

44. Wu L, Xun L, Yang J, Xu L, Tian Z, Gao S, Zhang Y, Hou P, Shi B. Induction of murine neonatal tolerance against Graves' disease using recombinant adenovirus expressing the TSH receptor A-subunit. Endocrinology. 2011 Mar;152(3):1165-71. doi: 10.1210/en.2010-0737.

45. Wang D, Cui W, Wu X, Qu Y, Wang N, Shi B, Hou P. RUNX3 site-specific hypermethylation predicts papillary thyroid cancer recurrence. Am J Cancer Res. 2014 Nov 19;4(6):725-37.

46. Qu Y, Dang S, Wu K, Shao Y, Yang Q, Ji M, Shi B, Hou P. TERT promoter mutations predict worse survival in laryngeal cancer patients. Int J Cancer. 2014 Aug 15;135(4):1008-10. doi: 10.1002/ijc.28728.

47. Dang S, Qu Y, Wei J, Shao Y, Yang Q, Ji M, Shi B, Hou P. Low copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in early-stage laryngeal cancer patients. Diagn Pathol. 2014 Feb 5;9:28. doi: 10.1186/1746-1596-9-28.

48. Zhang Y, Qu Y, Gao K, Yang Q, Shi B, Hou P, Ji M. High copy number of mitochondrial DNA (mtDNA) predicts good prognosis in glioma patients. Am J Cancer Res. 2015 Feb 15;5(3):1207-16.

49. Qu Y, Shi L, Wang D, Zhang B, Yang Q, Ji M, Shi B, Hou P. Low frequency of TERT promoter mutations in a large cohort of gallbladder and gastric cancers. Int J Cancer. 2014 Jun 15;134(12):2993-4. doi: 10.1002/ijc.28633.

50. Liu J, Zhao Z, Willcox MD, Xu B, Shi B. Multiplex bead analysis of urinary cytokines of type 2 diabetic patients with normo- and microalbuminuria. J Immunoassay Immunochem. 2010;31(4):279-89. doi: 10.1080/15321819.2010.524860.

51. Shi J, Qu Y, Li X, Sui F, Yao D, Yang Q, Shi B, Ji M, Hou P. Increased expression of EHF via gene amplification contributes to the activation of HER family signaling and associates with poor survival in gastric cancer. Cell Death Dis. 2016 Oct 27;7(10):e2442. doi: 10.1038/cddis.2016.346.

52. Shi J, Liu W, Sui F, Lu R, He Q, Yang Q, Lv H, Shi B, Hou P. Frequent amplification of AIB1, a critical oncogene modulating major signaling pathways, is associated with poor survival in gastric cancer. Oncotarget. 2015 Jun 10;6(16):14344-59. doi: 10.18632/oncotarget.3852.

53. Liu S, Zhang B, Zhao Y, Chen P, Ji M, Hou P, Shi B. Association of BRAFV600E mutation with clinicopathological features of papillary thyroid carcinoma: a study on a Chinese population. Int J Clin Exp Pathol. 2014 Sep 15;7(10):6922-8.

54. Liu X, Qiang W, Liu X, Liu L, Liu S, Gao A, Gao S, Shi B. A second course of antithyroid drug therapy for recurrent Graves' disease: an experience in endocrine practice. Eur J Endocrinol. 2015 Mar;172(3):321-6. doi: 10.1530/EJE-14-0704. Epub 2014 Dec 2.

55. Wang N, She J, Liu W, Shi J, Yang Q, Shi B, Hou P. Frequent amplification of PTP1B is associated with poor survival of gastric cancer patients. Cell Cycle. 2015;14(5):732-43. doi: 10.1080/15384101.2014.998047.

56. Qu Y, Yang Q, Liu J, Shi B, Ji M, Li G, Hou P. c-Myc is Required for BRAFV600E-Induced Epigenetic Silencing by H3K27me3 in Tumorigenesis. Theranostics. 2017 May 26;7(7):2092-2107. doi: 10.7150/thno.19884.

57. Liu L, Wu L, Gao A, Zhang Q, Lv H, Xu L, Xie C, Wu Q, Hou P, Shi B. The Influence of Dihydrotestosterone on the Development of Graves' Disease in Female BALB/c Mice. Thyroid. 2016 Mar;26(3):449-57. doi: 10.1089/thy.2015.0620. Epub 2016 Feb 12.

58. Ye F, Hou P, Wu X, Ma X, Gao L, Wu L, Xu L, Shi B. The significance of immune-related molecule expression profiles in an animal model of Graves' disease. Autoimmunity. 2012 Mar;45(2):143-52. doi: 10.3109/08916934.2011.611548. Epub 2011 Oct 21.

59. Wang N, Sui F, Ma J, Su X, Liu J, Yao D, Shi B, Hou P, Yang Q. Site-specific Hypermethylation of RUNX3 Predicts Poor Prognosis in Gastric Cancer. Arch Med Res. 2016 May;47(4):285-92. doi: 10.1016/j.arcmed.2016.07.011.

60. Zhang Y, Sui F, Ma J, Ren X, Guan H, Yang Q, Shi J, Ji M, Shi B, Sun Y, Hou P. Positive Feedback Loops Between NrCAM and Major Signaling Pathways Contribute to Thyroid Tumorigenesis. J Clin Endocrinol Metab. 2017 Feb 1;102(2):613-624. doi: 10.1210/jc.2016-1677.

61. Chen J, Wang S, Luo M, Zhang Z, Dai X, Kong M, Cai L, Wang Y, Shi B, Tan Y. From the Cover: Zinc Deficiency Worsens and Supplementation Prevents High-Fat Diet Induced Vascular Inflammation, Oxidative Stress, and Pathological Remodeling. Toxicol Sci. 2016 Sep;153(1):124-36. doi: 10.1093/toxsci/kfw110. Epub 2016 Jun 30.

62. Zhao Z, Ji L, Zheng L, Yang L, Yuan H, Chen L, Shan Z, Shen S, Li Q, Shi B, Liu Y, Ji Q, Bao Y, Gao X, Xie Y, Liu Y, Chen L, Han X, Wu F, Yang C, Du J, Gao Y, Zou D. Effectiveness of clinical alternatives to nerve conduction studies for screening for diabetic distal symmetrical polyneuropathy: A multi-center study. Diabetes Res Clin Pract. 2016 May;115:150-6. doi: 10.1016/j.diabres.2016.01.002. Epub 2016 Jan 18.

63. Zhang Y, Wu K, Shao Y, Sui F, Yang Q, Shi B, Hou P, Ji M. Decreased 5-Hydroxymethylcytosine (5-hmC) predicts poor prognosis in early-stage laryngeal squamous cell carcinoma. Am J Cancer Res. 2016 May 1;6(5):1089-98.

64. Guo F, Hou P, Shi B. Detection of BRAF mutation on fine needle aspiration biopsy specimens: diagnostic and clinical implications for papillary thyroid cancer. Acta Cytol. 2010 May-Jun;54(3):291-5. doi: 10.1159/000325037.

65. Wang N, Li Y, Wei J, Pu J, Liu R, Yang Q, Guan H, Shi B, Hou P, Ji M. TBX1 Functions as a Tumor Suppressor in Thyroid Cancer Through Inhibiting the Activities of the PI3K/AKT and MAPK/ERK Pathways. Thyroid. 2019 Mar;29(3):378-394. doi: 10.1089/thy.2018.0312.

66. Li Y, Yang Q, Guan H, Shi B, Ji M, Hou P. ZNF677 Suppresses Akt Phosphorylation and Tumorigenesis in Thyroid Cancer. Cancer Res. 2018 Sep 15;78(18):5216-5228. doi: 10.1158/0008-5472.CAN-18-0003.

67. Qiang W, Sui F, Ma J, Li X, Ren X, Shao Y, Liu J, Guan H, Shi B, Hou P. Proteasome inhibitor MG132 induces thyroid cancer cell apoptosis by modulating the activity of transcription factor FOXO3a. Endocrine. 2017 Apr;56(1):98-108. doi: 10.1007/s12020-017-1256-y. Epub 2017 Feb 20.

68. Liu W, Sui F, Liu J, Wang M, Tian S, Ji M, Shi B, Hou P. PAX3 is a novel tumor suppressor by regulating the activities of major signaling pathways and transcription factor FOXO3a in thyroid cancer. Oncotarget. 2016 Aug 23;7(34):54744-54757. doi: 10.18632/oncotarget.10753.

69. Wu LP, Shi BY, Xun LR, Guo LY, Yang J, Xu L. [An exploration of induction methodology and experimental duration of Graves disease animal model]. ZhonghuaNeiKe Za Zhi. 2012 Oct;51(10):793-7. Chinese.

70. Li H, Tian Z, Qu Y, Yang Q, Guan H, Shi B, Ji M, Hou P. SIRT7 promotes thyroid tumorigenesis through phosphorylation and activation of Akt and p70S6K1 via DBC1/SIRT1 axis. Oncogene. 2019 Jan;38(3):345-359. doi: 10.1038/s41388-018-0434-6.

71. Zhai X, Zhang L, Chen L, Lian X, Liu C, Shi B, Shi L, Tong N, Wang S, Weng J, Zhao J, Teng X, Yu X, Lai Y, Wang W, Li C, Mao J, Li Y, Fan C, Li L, Shan Z, Teng W. An Age-Specific Serum Thyrotropin Reference Range for the Diagnosis of Thyroid Diseases in Older Adults: A Cross-Sectional Survey in China. Thyroid. 2018 Dec;28(12):1571-1579. doi: 10.1089/thy.2017.0715. Epub 2018 Nov 27.

72. Ye F, Shi B, Wu X, Hou P, Gao L, Ma X, Xu L, Wu L. Experience with lentivirus-mediated CD40 gene silencing in a mouse model of Graves' disease. J Endocrinol. 2011 Mar;208(3):285-91. doi: 10.1677/JOE-10-0224. Epub 2010 Dec 8.

73. Liu JF, Shi BY. [Study on TR beta gene mutation in a thyroid hormone resistance syndrome family]. Zhonghua Yi Xue Yi ChuanXue Za Zhi. 2006 Aug;23(4):423-6. Chinese.

74. He Y, Zheng J, Zhang Q, Hou P, Zhu F, Yang J, Li W, Chen P, Liu S, Zhang B, Shi B. Association of HLA-B and HLA-DRB1 polymorphisms with antithyroid drug-induced agranulocytosis in a Han population from northern China. Sci Rep. 2017 Sep 20;7(1):11950. doi: 10.1038/s41598-017-12350-2.

75. Lv Y, Sui F, Ma J, Ren X, Yang Q, Zhang Y, Guan H, Shi B, Hou P, Ji M. Increased expression of EHF contributes to thyroid tumorigenesis through transcriptionally regulating HER2 and HER3. Oncotarget. 2016 Sep 6;7(36):57978-57990. doi: 10.18632/oncotarget.11154.

76. Zhang L, Shi J, Xu L, Shi B, Hou P, Ji M. Aberrant DNA methylation of drug metabolism and transport genes in nodular goiter. Thyroid Res. 2011 Oct 12;4(1):15. doi: 10.1186/1756-6614-4-15.

77. Wang Y, Zhao F, Rijntjes E, Wu L, Wu Q, Sui J, Liu Y, Zhang M, He M, Chen P, Hu S, Hou P, Schomburg L, Shi B. Role of Selenium Intake for Risk and Development of Hyperthyroidism. J Clin Endocrinol Metab. 2019 Feb 1;104(2):568-580. doi: 10.1210/jc.2018-01713.

78. Li M, Chen L, Qu Y, Sui F, Yang Q, Ji M, Shi B, Chen M, Hou P. Identification of MAP kinase pathways as therapeutic targets in gallbladder carcinoma using targeted parallel sequencing. Oncotarget. 2017 May 30;8(22):36319-36330. doi: 10.18632/oncotarget.16751.

79. Liu X, Shi B, Li H. Valuable predictive features of relapse of Graves' disease after antithyroid drug treatment. Ann Endocrinol (Paris). 2015 Dec;76(6):679-83. doi: 10.1016/j.ando.2015.08.004. Epub 2015 Oct 27.

80. Liu MM, Li Q, Zhao LL, Gao Y, Huang YY, Lu GZ, Gao YM, Guo XH, Shi BY. Glycosylation of recombinant human thyroid peroxidase ectodomain of insect cell origin has little effect on recognition by serum thyroid peroxidase antibody. Chin Med J (Engl). 2013;126(15):2907-11.

81. Lv Y, Zhang Y, Li X, Ren X, Wang M, Tian S, Hou P, Shi B, Yang Q. Long telomere length predicts poor clinical outcome in esophageal cancer patients. Pathol Res Pract. 2017 Feb;213(2):113-118. doi: 10.1016/j.prp.2016.11.010. Epub 2016 Nov 16.

82. Chen L, Wang C, Zhang X, Gao K, Liu R, Shi B, Hou P. AIB1 Genomic Amplification Predicts Poor Clinical Outcomes in Female Glioma Patients. J Cancer. 2016 Oct 22;7(14):2052-2060. doi: 10.7150/jca.16069.

83. Liu S, Hou P, Morahan G, Shi B. No association between IL12B gene polymorphisms and Graves' disease in the Chinese population. Endocr Res. 2012;37(4):182-7. doi: 10.3109/07435800.2012.663846. Epub 2012 May 23.

84. Xu J, Zhang W, Cui W, Shi B, Wang H. PKCα promotes insulin secretion via TRPC1 phosphorylation in INS-1E cells. BiosciBiotechnolBiochem. 2019 Sep;83(9):1676-1682. doi: 10.1080/09168451.2019.1617106. Epub 2019 May 16.

85. Dang S, Zhou J, Chen Y, Chen P, Ji M, Shi B, Yang Q, Hou P. Dynamic expression of ZNF382 and its tumor-suppressor role in hepatitis B virus-related hepatocellular carcinogenesis. Oncogene. 2019 Jun;38(24):4804-4819. doi: 10.1038/s41388-019-0759-9. Epub 2019 Feb 25.

86. Shibata Y, Bao L, Fu L, Shi B, Shi YB. Functional Studies of Transcriptional Cofactors via Microinjection-Mediated Gene Editing in Xenopus. Methods Mol Biol. 2019;1874:507-524. doi: 10.1007/978-1-4939-8831-0_29.

87. Ji M, Guan H, Shi B, Hou P. Concomitant hypermethylation of multiple genes in non-small cell lung cancer (NSCLC). Folia HistochemCytobiol. 2011;49(1):132-41. doi: 10.5603/fhc.2011.0019.

88.   Dai Guang-rong; Zhang Yong-li; Shi Bing-yin.Immunohistochemical localization of the calcitonin in the submandibular gland of rat.JiepouXuebao.Feb 2006.37:99-101.

89. Li X, Pu J, Liu J, Chen Y, Li Y, Hou P, Shi B, Yang Q. The prognostic value of DAPK1 hypermethylation in gliomas: A site-specific analysis. Pathol Res Pract. 2018 Jul;214(7):940-948. doi: 10.1016/j.prp.2018.05.023. Epub 2018 May 22.

90. Li H, Tian Z, Zhang Y, Yang Q, Shi B, Hou P, Ji M. Increased copy number of mitochondrial DNA predicts poor prognosis of esophageal squamous cell carcinoma. Oncol Lett. 2018 Jan;15(1):1014-1020. doi: 10.3892/ol.2017.7416. Epub 2017 Nov 15.

91. Lan L, Basourakos S, Cui D, Zuo X, Deng W, Huo L, Chen L, Zhang G, Deng L, Shi B, Luo Y. Inhibiting β-catenin expression promotes efficiency of radioiodine treatment in aggressive follicular thyroid cancer cells probably through mediating NIS localization. Oncol Rep. 2017 Jan;37(1):426-434. doi: 10.3892/or.2016.5228. Epub 2016 Nov 7.

92.    Li, Ya; Ma, Weiguo; Xie, Chuanqing; Zhang, Min; Yin, Xiaohong; Wang, Fenfen; Xu, Jie; Shi, Bingyin, Identification of genes and signaling pathways associated with diabetic neuropathy using a weighted correlation network analysis A consort study, MEDICINE,(2016).

93.   Wu, Li-Ping; Xun, Li-Ru; Xu, Li; Hussain, Amir; Shi, Bing-Yin, A Study on Neonatal Tolerance Against Graves' Disease in BALB/c Mice, CHINESE MEDICAL JOURNAL,(2015) 3243-3246.

94.  Zhao, Yanru; Guan, Xiaoyan; Liu, Yanjun; Liu, Shu; Hussain, Aamir; Shi, Bingyin, The efficacy of percutaneous AHI (arginine hydrochloride injection) for the treatment of recurrent thyroid cysts, ANNALES D ENDOCRINOLOGIE,(2015) 281-285.

95.    He, Yayi; Liu, Shu; Guo, Hui; Shi, Bingyin, Incidental finding of papillary thyroid carcinoma with BRAFV600E mutation in a patient with coexistent primary hyperparathyroidism and Graves' hyperthyroidism, BMJ case reports,(2014).

96.     Zhang, Fengchun; Liu, Zhichun; Jiang, Lindi; Zhang, Hao; Zhao, Dongbao; Li, Yang; Zou, Hejian; Wang, Xiaoyue; Li, Xiangpei; Shi, Bingyin; Xu, Jianhua; Yang, Hongjie; Hu, Shaoxian; Qu, Shen, A Randomized, Double-Blind, Non-Inferiority Study of Febuxostat Versus Allopurinol in Hyperuricemic Chinese Subjects With or Without Gout, RHEUMATOLOGY AND THERAPY,(2019) 543-557.

97.   He, Yizhi; Shi, Bingyin; Zhao, Xinrui; Sui, Jing, Sphingosine-1-phosphate induces islet beta-cell proliferation and decreases cell apoptosis in high-fat diet/streptozotocin diabetic mice, EXPERIMENTAL AND THERAPEUTIC MEDICINE,(2019)3415-3424.

98.    Sui, Jing; He, Mingqian; Wang, Yue; Zhao, Xinrui; He, Yizhi; Shi, Bingyin, Sphingolipid metabolism in type 2 diabetes and associated cardiovascular complications,  EXPERIMENTAL AND THERAPEUTIC MEDICINE,(2019)3603-3614.

99.    Zhao, Fengyi; Wu, Liping; Wang, Yue; Liu, Lianye; Yang, Fei; Sun, Yushi; Jiao, Xiang; Bao, Lingyu; Chen, Pu; Liang, Qiangrong; Shi, Bingyin, Dihydrotestosterone regulates oxidative stress and immunosuppressive cytokines in a female BALB/c mouse model of Graves' disease, AUTOIMMUNITY,(2019)117-125.

100.     Bao, Lingyu; Roediger, Julia; Park, Sunmi; Fu, Liezhen; Shi, Bingyin; Cheng, Sheue-Yann; Shi, Yun-Bo, Thyroid Hormone Receptor Alpha Mutations Lead to Epithelial Defects in the Adult Intestine in a Mouse Model of Resistance to Thyroid Hormone, THYROID, (2019)439-448.

101.     Sui, Fang; Sun, Wanjing; Su, Xi; Chen, Pu; Hou, Peng; Shi, Bingyin; Yang, Qi,  Gender-related differences in the association between concomitant amplification of AIB1 and HER2 and clinical outcomes in glioma patients, PATHOLOGY RESEARCH AND PRACTICE, (2018)1253-1259

102.     Zhao, Yang; Guo, Hui; Zhao, Ying; Shi, Bingyin, Secreting ectopic adrenal adenoma: A rare condition to be aware of, ANNALES D ENDOCRINOLOGIE, (2018)75-81.

103.   Sun, Yushi; Lv, Hongjun; Zhang, Shaoqiang; Bai, Yanxia; Shi, Bingyin, Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma, INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, (2018)

104.     Lan, Ling; Basourakos, Spyros; Cui, Dai; Zuo, Xuemei; Deng, Wei; Huo, Lili; Chen, Hailing; Zhang, Guoying; Deng, Lili; Shi, Bingyin; Luo, Yong, ATRA increases iodine uptake and inhibits the proliferation and invasiveness of human anaplastic thyroid carcinoma SW1736 cells: Involvement of beta-catenin phosphorylation inhibition, ONCOLOGY LETTERS, (2017)7733-7738.

105.     Sun, Y S; Lyu, H J; Zhao, Y R; Zhang, S S; Bai, Y X; Shi, B Y, Risk factors for central neck lymph node metastases of papillary thyroid carcinoma, Chinese journal of otorhinolaryngology head and neck surgery, (2017)421-425.

106.     Activated ERK: An Emerging Player in miRNA Downregulation, TRENDS IN CANCER, (2017)163-165.

107.     Zhang, Huairong; Hu, Xiaowen; Wu, Qian; Shi, Bingyin,  Qu, Yiping; Shi, Bingyin; Hou, Peng, Impact of diabetes on bleeding events in ST-elevation myocardial infarction patients after urgent percutaneous coronary intervention A retrospective cohort study, MEDICINE, (2016).

108.     Liu, Xingjun; Liu, Jingfang; Fan, Liya; Shi, Bingyin, Erythrocytosis associated with hyperthyroidism: a rare case report and clinical study of possible mechanism, ENDOCRINE RESEARCH,(2015)177-180.

109.    Li, Yan; Li, Na; Han, Qunying; He, Shuixiang; Bae, Ricard S.; Liu, Zhengwen; Lv, Yi; Shi, Bingyin,Performance of Physical Examination Skills in Medical Students during Diagnostic Medicine Course in a University Hospital of Northwest China, PLOS ONE,(2014).

110.     Yan, Li-ying; Li, Sui-qin; Shi, Bing-yin; Zhang, Shao-qiang; Bai, Yan-xia; Quan, Fang; Wang, Lin-gu; He, Wen-xuan, Surgical treatment of hyperthyroidism, Chinese journal of otorhinolaryngology head and neck surgery,（2006）595

111.     Li, Yongze; Teng, Di; Shi, Xiaoguang; Qin, Guijun; Qin, Yingfen; Quan, Huibiao; Shi, Bingyin; Sun, Hui; Ba, Jianming; Chen, Bing; Du, Jianling; He, Lanjie; Lai, Xiaoyang; Li, Yanbo; Chi, Haiyi; Liao, Eryuan; Liu, Chao; Liu, Libin; Tang, Xulei; Tong, Nanwei; Wang, Guixia; Zhang, Jin-an; Wang, Youmin; Xue, Yuanming; Yan, Li; Yang, Jing; Yang, Lihui; Yao, Yongli; Ye, Zhen; Zhang, Qiao; Zhang, Lihui; Zhu, Jun; Zhu, Mei; Ning, Guang; Mu, Yiming; Zhao, Jiajun; Teng, Weiping; Shan, Zhongyan，Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study， BMJ-BRITISH MEDICAL JOURNAL，（2020）

112. Jin, Mingyue; Zhang, Zhuo; Li, Yongze; Teng, Di; Shi, Xiaoguang; Ba, Jianming; Chen, Bing; Du, Jianling; He, Lanjie; Lai, Xiaoyang; Teng, Xiaochun; Li, Yanbo; Chi, Haiyi; Liao, Eryuan; Liu, Chao; Liu, Libin; Qin, Guijun; Qin, Yingfen; Quan, Huibiao; Shi, Bingyin; Sun, Hui; Tang, Xulei; Tong, Nanwei; Wang, Guixia; Zhang, Jin-an; Wang, Youmin; Xue, Yuanming; Yan, Li; Yang, Jing; Yang, Lihui; Yao, Yongli; Ye, Zhen; Zhang, Qiao; Zhang, Lihui; Zhu, Jun; Zhu, Mei; Ning, Guang; Mu, Yiming; Zhao, Jiajun; Teng, Weiping; Shan, Zhongyan,U-Shaped Associations Between Urinary Iodine Concentration and the Prevalence of Metabolic Disorders: A Cross-Sectional Study, THYROID,(2020)

113.     Wu, Ying; Shi, Xiaoguang; Tang, Xulei; Li, Yongze; Tong, Nanwei; Wang, Guixia; Zhang, Jin-An; Wang, Youmin; Ba, Jianming; Chen, Bing; Du, Jianling; He, Lanjie; Lai, Xiaoyang; Li, Yanbo; Chi, Haiyi; Liao, Eryuan; Liu, Chao; Liu, Libin; Qin, Guijun; Qin, Yingfen; Quan, Huibiao; Shi, Bingyin; Sun, Hui; Xue, Yuanming; Yan, Li; Yang, Jing; Yang, Lihui; Yao, Yongli; Ye, Zhen; Zhang, Qiao; Zhang, Lihui; Zhu, Jun; Zhu, Mei; Teng, Weiping; Shan, Zhongyan,THE CORRELATION BETWEEN METABOLIC DISORDERS AND TPOAB/TGAB: A CROSS-SECTIONAL POPULATION-BASED STUDY, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists,(2020)

114.     Li, Yongze; Teng, Di; Ba, Jianming; Chen, Bing; Du, Jianling; He, Lanjie; Lai, Xiaoyang; Teng, Xiaochun; Shi, Xiaoguang; Li, Yanbo; Chi, Haiyi; Liao, Eryuan; Liu, Chao; Liu, Libin; Qin, Guijun; Qin, Yingfen; Quan, Huibiao; Shi, Bingyin; Sun, Hui; Tang, Xulei; Tong, Nanwei; Wang, Guixia; Zhang, Jin-An; Wang, Youmin; Xue, Yuanming; Yan, Li; Yang, Jing; Yang, Lihui; Yao, Yongli; Ye, Zhen; Zhang, Qiao; Zhang, Lihui; Zhu, Jun; Zhu, Mei; Ning, Guang; Mu, Yiming; Zhao, Jiajun; Shan, Zhongyan; Teng, Weiping,Efficacy and Safety of Long-Term Universal Salt Iodization on Thyroid Disorders: Epidemiological Evidence from 31 Provinces of Mainland China, THYROID,(2020)568-579.

115.     Zhang, Jinjia; Gao, Yiyang; Li, Yongze; Teng, Di; Xue, Yuanming; Yan, Li; Yang, Jing; Yang, Lihui; Yao, Yongli; Ba, Jianming; Chen, Bing; Du, Jianling; He, Lanjie; Lai, Xiaoyang; Teng, Xiaochun; Shi, Xiaoguang; Li, Yanbo; Chi, Haiyi; Liao, Eryuan; Liu, Chao; Liu, Libin; Qin, Guijun; Qin, Yingfen; Quan, Huibiao; Shi, Bingyin; Sun, Hui; Tang, Xulei; Tong, Nanwei; Wang, Guixia; Zhang, Jin-an; Wang, Youmin; Ye, Zhen; Zhang, Qiao; Zhang, Lihui; Zhu, Jun; Zhu, Mei; Teng, Weiping; Shan, Zhongyan; Li, Jing,The Presence of Serum TgAb Suggests Lower Risks for Glucose and Lipid Metabolic Disorders in Euthyroid General Population From a National Survey, FRONTIERS IN ENDOCRINOLOGY,(2020).

116.      Lu, Xixuan; Shi, Xiaoguang; Li, Yanbo; Chi, Haiyi; Liao, Eryuan; Liu, Chao; Liu, Libin; Li, Yongze; Teng, Di; Teng, Xiaochun; Ba, Jianming; Chen, Bing; Du, Jianling; He, Lanjie; Lai, Xiaoyang; Qin, Guijun; Qin, Yingfen; Quan, Huibiao; Shi, Bingyin; Sun, Hui; Tang, Xulei; Tong, Nanwei; Wang, Guixia; Zhang, Jin-an; Wang, Youmin; Xue, Yuanming; Yan, Li; Yang, Jing; Yang, Lihui; Yao, Yongli; Ye, Zhen; Zhang, Qiao; Zhang, Lihui; Zhu, Jun; Zhu, Mei; Shan, Zhongyan; Teng, Weiping,A negative association between urinary iodine concentration and the prevalence of hyperuricemia and gout: a cross-sectional and population-based study in Mainland China, EUROPEAN JOURNAL OF NUTRITION, (2020).

117.     Chen, Ziyi; Wang, Yue; Ding, Xi; Zhang, Meng; He, Mingqian; Zhao, Yang; Hu, Shiqian; Zhao, Fengyi; Wang, Jingya; Xie, Baosong; Shi, Bingyin,The proportion of peripheral blood Tregs among the CD4+T cells of autoimmune thyroid disease patients: a meta-analysis , ENDOCRINE JOURNAL ,(2020)317-326.

118.    Liu, L Y; Shi, B Y; Wu, L P; Gao, A B,The influence of dihydrotestosterone on cytokine releases in male mice model with Graves disease , Zhonghuaneike za zhi ,(2020)47-51.

119.     Sui, Jing; Shi, Bingyin; Hu, Yinghui; Deng, Mei; Wang, Yue; He, Mingqian; Zhao, Xinrui; Ji, Qiuhe; Ming, Jie; Yao, Xiaoli, Islet Function Changes Among the Elderly Population, ARCHIVES OF MEDICAL RESEARCH,(2019)468-475.

120.     Wei, Jing; Yang, Qi; Shi, Jing; Shi, Bingyin; Ji, Meiju; Hou, Peng, Increased expression of NAF1 contributes to malignant phenotypes of glioma cells through promoting protein synthesis and associates with poor patient survival, ONCOGENESIS,(2019).

121.    Hu, Shiqian; Wang, Yue; He, Mingqian; Zhang, Meng; Ding, Xi; Shi, Bingyin,Factors associated with the efficacy of intravenous methylprednisolone in moderate-to-severe and active thyroid-associated ophthalmopathy: A single-centre retrospective study, CLINICAL ENDOCRINOLOGY,(2019)175-183.

122.    Liu, Shu; Zhao, Yanru; Li, Miaojing; Xi, Jieying; Shi, Bingyin; Zhu, Huachao,Simultaneous Hodgkin lymphoma and BRAF(V600E)-positive papillary thyroid carcinoma A case report, MEDICINE,(2019).

123.     Zhang, Yan; Shi, Lixin; Zhang, Qiao; Peng, Nianchun; Chen, Lulu; Lian, Xiaolan; Liu, Chao; Shan, Zhongyan; Shi, Bingyin; Tong, Nanwei; Wang, Shu; Weng, Jianping; Zhao, Jiajun; Teng, Weiping,The association between cigarette smoking and serum thyroid stimulating hormone, thyroid peroxidase antibodies and thyroglobulin antibodies levels in Chinese residents: A cross-sectional study in 10 cities, PloS one,(2019) e0225435.

124.     Li, Yiqi; Li, Xinru; Pu, Jun; Yang, Qi; Guan, Haixia; Ji, Meiju; Shi, Bingyin; Chen, Mingwei; Hou, Peng,c-Myc Is a Major Determinant for Antitumor Activity of Aurora A Kinase Inhibitor MLN8237 in Thyroid Cancer, THYROID,(2018)1642-1654.

125.     Xu, Jingyi; Qiu, Xing; Liang, Zhou; Smiley-Jewell, Suzette; Lu, Faqiang; Yu, Mang; Pinkerton, Kent E.; Zhao, Dewei; Shi, Bingyin,Exposure to tobacco smoke increases bone loss in spontaneously hypertensive rats,INHALATION TOXICOLOGY,(2018)229-238.

126.     Wei, Yang; Hu, Zhansheng; Gu, Wen; Liu, Gang; Shi, Bingyin; Liu, Enqi; Liu, Tie, CD117(+)CD44(+) Stem T Cells Develop in the Thymus and Potently Suppress T-cell Proliferation by Modulating the CTLA-4 Pathway, STEM CELL RESEARCH & THERAPY,(2017)

127.     Liu, Tie; Wei, Yang; Liu, Gang; Shi, Bingyin; Giovanni, Suarez; Peterson, Johnny W.; Chopra, Ashok K,A mutated cholera toxin without the ADP-ribosyltransferase activity induces cytokine production and inhibits apoptosis of splenocytes in mice possibly via toll-like receptor-4 signaling, MOLECULAR

128.    Zhang, Huairong; Gao, Bo; Shi, Bingyin,Identification of Differentially Expressed Kinase and Screening Potential Anticancer Drugs in Papillary Thyroid Carcinoma, Disease markers,(2016)2832980.

129.     Liu, Xiaomei; Guo, Hui; Dahal, Mahesh; Shi, Bingyin, Unusual presentation of two Chinese phenylketonuria sisters who were misdiagnosed for years, BMJ case reports,(2013).

130.    Zhou Shuhong; LvHongjun; Cui Bo; Xu Li; Shi Bingyin,The Effect of Dantonic Pill on beta-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy, JOURNAL OF DIABETES RESEARCH,(2013).

131.      He, Yayi; Shi, Bingyin; Wu, Xiaoyan; Hou, Peng; Wang, Yi，Emphysematous pyelonephritis treated with elective nephrectomy in a 75-year-old diabetic patient，Clinics and practice，(2012)e14.

132.    Zhang Yong-Li; Li She-Li; Li Bao-Li; Wang Yan-lin; Shi Bing-yin; Lu Shuang-yan; Li Ya,Study on the Localization of Calcitonin in the Submandibular Gland Cells of Rats, Journal of China Medical University,(2011)891-893.

133.    Zhang Jin'an; Shi Bingyin; Luo Wentian, Expression of apoptosis related antigen Fas and Bcl-2 in the thyroid tissues of autoimmune thyroid disease, Xi'an YikeDaxueXuebao,(2001),38-40.


Chinese Articles:

1. 施秉银,赵媛.甲状腺细针抽吸细胞学检查及临床应用评价[J].中华内分泌代谢杂志,2004(02):92-94.

2. 崔巍,施秉银.自身免疫性甲状腺疾病患者甲状腺内Th_1/Th_2细胞失衡研究[J].中华内分泌代谢杂志,2004(02):8-11.

3. 李蒙,李婷,施秉银,高翠霞.动机性访谈对长期血糖控制不良2型糖尿病患者生存质量及其相关因素的影响[J].中华护理杂志,2014,49(01):6-10.

4. 伍丽萍,施秉银,郭丽英,徐利,兰玲,刘娟,张进安,旬利茹.在雌性小鼠制备Graves病动物模型[J].中华内分泌代谢杂志,2006(04):388-391.

5. 施秉银.甲状腺结节和肿瘤的诊断、治疗与展望[J].中华内分泌代谢杂志,2003(02):7-9.

6. 刘星君,滕卫平,施秉银,魏丹国,段培真,李丽莉,路万虹,樊萍,李娟.健康成人甲状腺结节4306例患病情况调查[J].第四军医大学学报,2009,30(19):1982-1984.

7. 施秉银.积极推进我国甲状腺结节和肿瘤诊治的规范化[J].中华内分泌代谢杂志,2010(10):833-834.

8. 党珊,施秉银.Graves病患者CD4~+CD25~+调节性T细胞的变化[J].中华内分泌代谢杂志,2007,23(03):253-254.

9. 袁戈恒,郭晓蕙,冉兴无,薛耀明,杨毅华,苏本利,文重远,施秉银,吕肖峰,朱旅云,杨静,许樟荣,张勇,赵敏,白雨.重组人血小板源生长因子凝胶剂治疗慢性糖尿病足溃疡的临床疗效及安全性评价[J].中国临床药理学杂志,2015,31(06):424-428.

10. 刘星君,施秉银,王毅,李晓晖.超声在甲状腺结节处理中的价值:123例甲状腺结节患者超声声像图分析[J].中华内分泌代谢杂志,2010(11):963-966.

11. 施秉银.重视甲状腺疾病的规范化诊断与治疗[J].中华内分泌代谢杂志,2006(02):99-100.

12. 赵媛; 张杨; 刘星君; 侯鹏; 施秉银，分化型甲状腺癌预后相关因素分析并文献复习，中华内分泌代谢杂志，(2011).920-922.

13. 樊萍; 施秉银; 郭辉; 徐利，甲泼尼松龙冲击治疗甲状腺相关性眼病时 TRAb和sICAM-1的变化及意义，中华内分泌代谢杂志，(2010) 859-862.

14. 刘靖芳; 施秉银，甲状腺激素不敏感综合征分子机制的研究进展，中华内分泌代谢杂志，.(2008) 683-685.

15. 路万虹; 张晓田; 成少利; 施秉银，复方丹参滴丸对大鼠糖尿病肾病早期的肾脏保护及作用机制，西安交通大学学报（医学版），（2016）128-133.

16.    施秉银，甲状腺结节性质评估的未尽探索，中华内分泌代谢杂志，（2013）545-547.

17.    隋婧; 郭辉; 王毅; 赵菁; 施秉银，异位ACTH综合征的临诊应对，中华内分泌代谢杂志，（2013）714-718.

18.    王毅; 张少华; 施秉银，胰岛素样因子3受体(LGR8)在生精细胞与精子顶体中表达，中华内分泌代谢杂志，（2012）156-159

19.    贺雅毅; 韦妙; 施秉银，54例希恩综合征患者临床特征分析及文献复习，中华内分泌代谢杂志，（2012）557-560.

20.    戴盈; 崔巍; 施秉银，早期胰岛素抵抗胰岛beta细胞代偿机制的研究进展，中华内分泌代谢杂志，（2008）345-347.

21.    郭辉; 施秉银; 何辉，以特殊临床表现为首发症状的10例嗜铬细胞瘤临床诊治分析，中国实用内科杂志，（2006）1817-1818.

22.    贺雅毅; 强薇; 赵艳茹; 郑婕; 邓梅; 施秉银，抗甲状腺药物致粒细胞缺乏症并死亡病例的临床分析，西安交通大学学报（医学版），(2020)114-119.

23.    贺雅毅; 施秉银，甲巯咪唑致Graves病患者粒细胞缺乏症合并败血症的临床特征分析，药物不良反应杂志，（2019）366-371.

24.    梁亚茹; 姚孝礼; 施秉银，米非司酮治疗隐匿性异位促肾上腺皮质激素综合征的临床观察及文献回顾，中华内分泌代谢杂志，（2019）506-510.

25.    人TSHR A亚单位重组腺相关病毒2/9载体的构建及鉴定，赵凤仪; 何明倩; 王悦; 张萌; 胡诗倩; 施秉银; 伍丽萍，西安交通大学学报（医学版），（2019）997-1001.

26.    强薇; 袁佳; 陈谱; 施秉银，Notch家族成员遗传学变异预示乳头状甲状腺癌高复发风险，西安交通大学学报（医学版），（2018）691-697.

27.    隋婧; 和一之; 邓梅; 赵心蕊; 施秉银，1-磷酸鞘氨醇对2型糖尿病小鼠胰岛beta细胞损伤的保护作用，西安交通大学学报（医学版）（2018）831-838.

28. 施秉银，硒对甲状腺影响的探索与发现，中华内分泌代谢杂志，（2016）4-5.

29.    张伟; 许静; 汤小江; 王婷; 何建军; 施秉银; 王惠芳; 王丽君，大鼠急性心肌梗死模型建立的影响因素，西安交通大学学报（医学版），（2016）209-214.

30.    段静怡; 施秉银，淋巴细胞性垂体炎误诊为垂体腺瘤手术一例，中华内分泌代谢杂志，（2015）465-467.

31.    冯佳; 施秉银; 刘淑; 高爱博，载脂蛋白A5基因多态性与代谢综合征的相关性，西安交通大学学报（医学版），（2015）661-666.

32.    刘淑; 高爱博; 赵艳茹; 祭美菊; 侯鹏; 施秉银，影响甲状腺乳头状癌临床病理特征的相关因素分析，中华内分泌代谢杂志，（2015）941-945.

33.    陈欢; 汪宁; 崔巍; 施秉银，甲状腺激素不敏感综合征的发病机制和诊疗进展，中华内分泌代谢杂志，（2014）629-632.

34.    王悦; 伍丽萍; 施秉银; 浮姣; 吕宏军; 关晓燕; 徐利; 陈谱; 高楚淇; 侯鹏; 祭美菊，实验性猕猴Graves 病模型的制备，中华内分泌代谢杂志，（2014）606-610.

35.    叶枫; 伍丽萍; 侯鹏; 马晓丹; 高雷; 徐利; 吴晓燕; 施秉银， Graves病动物模型干预模式的探讨，西安交通大学学报（医学版），（2014）222-226.

36.    隋婧; 姜方旭; 施秉银，胚胎干细胞体外定向分化为Ngn3~+胰岛祖细胞的基因表达谱分析，中华内分泌代谢杂志，（2012）460-466.

37.    伍丽萍; 旬利茹; 施秉银; 杨靖; 徐利; 田竹芳; 高珊; 张煜，诱导新生小鼠对Graves病免疫耐受的研究，中华内分泌代谢杂志，（2012）744-749.

38.    张永莉; 李宝莉; 李社莉; 施秉银; 王炎林，大鼠颌下腺细胞中降钙素的定位及含量测定，西安交通大学学报（医学版），（2012）169-170.

39.    周淑红; 李蒙; 施秉银; 崔波; 吕宏军; 徐利，信号蛋白Smad1对2型糖尿病肾病诊断意义的初步研究，中国全科医学，（2012）1127-1129.

40.    吕晓虹; 冯小刚; 何岚; 施秉银; 王怀宇; 蒲丹; 孙怡宁; 周文旭，T2DM患者外周血单个核细胞中NF-kappaB的表达变化及其相关因素的探讨，西安交通大学学报（医学版），（2011）716-721.

41.    吕晓虹; 何岚; 施秉银; 蒲丹; 孙怡宁; 周文旭; 薛晓荣，类风湿关节炎患者胰岛素抵抗状况的评价，西安交通大学学报（医学版），（2011）89-92.

42.    隋婧; 姜方旭; 施秉银，多步骤诱导逐步筛选法建立高效的胚胎干细胞定向分化为胰岛祖细胞的分化方案，西安交通大学学报（医学版），（2011）407-413.

43.    施秉银，甲状腺功能亢进症的治疗现状与展望，西安交通大学学报（医学版），（2008）361-364.

44.    戴光荣; 张永莉; 施秉银，粒-巨噬细胞集落刺激因子对大鼠降钙素水平的影响，西安交通大学学报（医学版），（2007）67-69.

45.    武敏; 施秉银; 伍丽萍; 兰玲; 吴小燕; 张进安; 徐莉，人TSHR膜外区cDNA克隆及真核表达载体的构建，西安交通大学学报（医学版），（2007）123-125.

46.    郭辉; 张雅利; 王淑梅; 施秉银，系统性红斑狼疮患者胰岛素抵抗情况和胰岛beta细胞功能的评价，西安交通大学学报（医学版），（2006）569-571.

47.    刘靖芳; 施秉银; 王毅，Graves甲状腺功能亢进症继发红细胞增多症一例，（2006）187-188.

48.    施秉银; 李昊，甲状腺肿瘤蛋白质组学研究进展，西安交通大学学报（医学版），（2006）209-211    

49. 张芬茹; 施秉银; 李积厚; 薛建军; 高信曜，干燥综合征腮腺核素动态显像的影像特征及应用价值，中国医学影像技术，（2006）144-146.

50. 龚益; 施秉银; 崔燕; 赵媛，自身免疫性甲状腺病的病因探讨，西安交通大学学报（医学版），（2005）297-409.

51.    施秉银，胰岛干细胞的研究现状与展望，西安交通大学学报（医学版），（2005）409-412.

52.    王毅; 施秉银; 戴亚丽; 李雪萍，细胞凋亡与桥本氏甲状腺炎发病相关研究，西安交通大学学报（医学版），（2003）47-49.


The Publications of monograph

Modern diagnosis and treatment of thyroid diseases. Editor-in-chief. Shaanxi Science andTechnology Press, 1998

Basic and clinical endocrinology. The master Translator. World Books Press Xi 'an Co. Ltd, 2000

Endocrinology Manual. Editor-in-chief. Shaanxi Science andTechnology Press,Science press(China),2008