张亚光

日期：2023年10月12日


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张亚光 特聘研究员/副教授

硕士/博士生导师

联系电话：15821395312

邮箱：zhangyaguang@xjtu.edu.cn；

          zyg0abc@163.com

2008年-2012年，就读于四川大学生命科学学院；2012年-2018年，保送至中国科学院大学上海生物化学与细胞生物学研究所攻读硕博连读研究生学位（导师：孙兵研究员）；2019-2021年，在中国科学院分子细胞科学卓越创新中心（原上海生化细胞所）完成博士后训练（合作导师：王红艳研究员）；2021年-2023年，博士后出站后留所工作任副研究员岗位；2023年9月全职加入西安交通大学第一附属医院Med-X研究院免疫代谢性疾病研究所，任特聘研究员/副教授，组建分子免疫学课题组。入选西安交通大学“青年拔尖人才(B)类”和中国科学院青年创新促进会（第12批会员），获得第十一届中国免疫学会学术奖-青年学者奖。主持和参与多项国家和省部级学科基金项目；参与申请多项发明专利，已授权3项，许可1项；近五年，在国内外专业领域权威期刊（IF>10）共发表研究论文20多篇，总引用次数超过1400次，其中以第一作者（含共一）或通讯作者（含共同）发表文章13篇，文章发表在Nature Immunology (2022)、Nature Communications (2023)、Cellular & Molecular Immunology (2020, 2020, 2020, 2023, 2023)、Cell Discovery (2023)、Allergy (2023)、PNAS (2020)、Sci China Life Sci (2021)、OncoImmunology (2023)、Int J Mol Sci (2022)等国内外学术期刊。详见https://www.researchgate.net/profile/Yaguang-Zhang

研究方向：

分子免疫学课题组主要从临床疾病中发现科学问题，通过构建动物模型，利用组学数据分析和免疫学技术手段探究免疫系统与其它系统的相互作用分子机制，进而发现疾病发生的底层机制，寻找疾病潜在的治疗新靶点，并研发可能的候选药物。课题组聚焦呼吸系统炎症免疫反应，通过研究免疫系统和神经系统、内分泌系统、凝血系统、上皮屏障系统以及外界环境刺激因素等（包括过敏原、烟雾、病毒等）之间的相互作用，已经发现了包括a-MSH/MC5R、5-HT/HTR2A、GSDMD、VB6/MDM2、THROMBIN等多种调控肺部炎症的全新分子调控机制。未来，课题组将围绕自身免疫性疾病和代谢性疾病，重点研究免疫细胞在疾病环境下的功能调控机制，并通过mRNA技术开发潜在的治疗新途径。

1. 探究免疫细胞（二型先天样淋巴细胞、调节性T细胞、巨噬细胞等）在代谢相关疾病中的作用机制；

2. 探究环境因素（过敏原、烟雾、微生物等）对肺部免疫系统影响的分子机制；

3. 针对过敏性和自身免疫性疾病，开发具有治疗功能的mRNA疫苗药物。

探究免疫系统与其它系统（神经系统、内分泌系统、上皮屏障系统以及外界环境刺激因素等）之间的相互作用，解释疾病发生分子机制，并研发潜在治疗手段。

主要贡献论文 (第一作者标注#，通讯作者标注*)

1) Yuying Huang#, Lin Zhu#, Shipeng Cheng#, Ranran Dai#, Chunrong Huang#, Yanyan Song, Bo Peng, Xuezhen Li, Jing Wen, Yi Gong, Yunqian Hu, Ling Qian, Linyun Zhu, Fengying Zhang, Li Yu, Chunyan Yi, Wangpeng Gu, Zhiyang Ling, Liyan Ma, Wei Tang*, Li Peng*, Guochao Shi*, Yaguang Zhang*, Bing Sun*. Solar ultraviolet B radiation promotes α-MSH secretion to attenuate the function of ILC2s via the pituitary–lung axis. Nat Commun. 2023 Sep 12;14(1):5601 (5-Year IF: 17.0)

2) Jing Wen#, Shipeng Cheng#, Ran Wang#, Yuying Huang#, Long Xu#, Liyan Ma, Zhiyang Ling, Jinfu Xu*, Deping Zhao*, Yaguang Zhang#*, Bing Sun*. Group 2 innate lymphoid cells boost CD8+ T-cell activation and synergize with anti-PD-1 treatment in antitumour immune responses. OncoImmunology. 2023 Aug 9;12(1):2243112. (5-Year IF: 7.6)

3) Wangpeng Gu#, Jia Zhang#, Qing Li#, Yaguang Zhang#*, Xuan Lin#, Bingbing Wu#, Qi Yin#, Jinqiao Sun, Yulan Lu, Xiaoyu Sun, Caiwei Jia, Chuanyin Li, Yu Zhang, Meng Wang, Xidi Yin, Su Wang, Jiefang Xu, Ran Wang, Songling Zhu, Shipeng Cheng, Shuangfeng Chen, Lian Liu, Lin Zhu, Chenghua Yan, Chunyan Yi, Xuezhen Li, Qiaoshi Lian, Guomei Lin, Zhiyang Ling, Liyan Ma, Min Zhou, Kuanlin Xiao, Ze Chen, Dangsheng Li, Haiming Wei, Ronggui Hu*, Wenhao Zhou*, Lilin Ye*, Haikun Wang*, Jinsong Li* and Bing Sun*. The Trim37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation. Cell Discov 2023 Aug 1;9(1):82. (5-Year IF:21.9)

4) Songling Zhu#, Shufen Zhong#, Kebin Cheng#, Li-Sha Zhang#, Jiu-wu Bai, Zu Cao, Su Wang, Wen Chen, Shipeng Cheng, Liyan Ma, Zhiyang Ling, Yuying Huang, Wangpeng Gu, Xiaoyu Sun, Chunyan Yi, Meng Zhao, Shuo Liang*, Jin-Fu Xu*, Bing Sun*, Yaguang Zhang*. Vitamin B6 regulates MDM2-mediated IL-33 homeostasis to constrain the type 2 inflammation. Cell Mol Immunol. 2023 Jul;20(7):794-807 (5-Year IF:19.1)

5) Zhishuo Wang#, Chenghua Yan#, Qizhen Du#, Yuying Huang#, Xuezhen Li#, Dan Zeng#, Ruizhi Mao#, Rama Krishna Gurram, Shipeng Cheng, Wangpeng Gu, Lin Zhu, Weiguo Fan, Liyan Ma, Zhiyang Ling, Ju Qiu, Dangsheng Li, Enmei Liu*, Yaguang Zhang*, Yiru Fang*, Jinfang Zhu*, Bing Sun*. HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation. Cell Mol Immunol. 2023 Apr;20(4):404-418. (5-Year IF:19.1)

6) Wen Chen#, Shuangfeng Chen#, Chenghua Yan#, Yaguang Zhang#*, Ronghua Zhang#, Min Chen#, Shufen Zhong, Weiguo Fan, Songling Zhu, Danyan Zhang, Xiao Lu, Jia Zhang, Yuying Huang, Lin Zhu, Xuezhen Li, Dawei Lv, Yadong Fu, Houkun Lv, Zhiyang Ling, Liyan Ma, Hai Jiang, Gang Long, Jinfang Zhu, Dong Wu*, Bin Wu*, Bing Sun*. Allergen proteases-activated stress granules assembly and Gsdmd fragmentation control IL-33 secretion. Nat Immunol. 2022 Jul;23(7):1021-1030. (5-Year IF:29.6)

7) Yuying Huang#, Xuezhen Li#, Lin Zhu#, Chunrong Huang#, Wen Chen, Zhiyang Ling, SongLing Zhu, Xintong Feng, Chunyan Yi, Wangpeng Gu, Chenghua Yan, Jing Wang, Liyan Ma, Xiao Su, Ranran Dai*, Guochao Shi*, Bing Sun*, Yaguang Zhang*. Thrombin cleaves IL-33 and modulates IL-33-activated allergic lung inflammation. Allergy. 2022 Jul;77(7):2104-2120. (5-Year IF:10.4)

8) Danyan Zhang, Yaguang Zhang*, Bing Sun*. The Molecular Mechanisms of Liver Fibrosis and Its Potential Therapy in Application. Int J Mol Sci. 2022 Oct 20;23(20):12572. (5-Year IF:6.2) (Review)

9) Jing Wen#, Shipeng Cheng#, Yaguang Zhang#*, Ran Wang, Jiefang Xu, Zhiyang Ling, Liyan Ma, Xinghao Ai*, Bing Sun*. Lactate is critical for cytokine production in T cells after TCR activation. Sci China Life Sci. 2021 Nov;64(11):1895-1905. (5-Year IF: 7.1)

10) Qiaoshi Lian#; Shanshan Yan#; Qi Yin#; Chenghua Yan#; Wanwei Zheng; Wangpeng Gu; Xinhao Zhao; Weiguo Fan; Xuezhen Li; Liyan Ma; Zhiyang Ling; Yaguang Zhang*; Jie Liu*; Jinsong Li*; Bing Sun*. TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity. Cell Mol Immunol, 18, 350–362 (2020). (5-Year IF:19.1)

11) Yaguang Zhang#, Xiaojing Wang#, Xuezhen Li#, Dong Xi#, Ruizhi Mao, Xiaohui Wu, Shipeng Cheng, Xiaoyu Sun,Chunyan Yi, Zhiyang Ling, Liyan Ma, Qin Ning, Yiru Fang*, Bing Sun*, Di Wu*. Potential contribution of increased soluble IL-2R to lymphopenia in COVID-19 patients. Cell Mol Immunol, 17, 878–880(2020). (5-Year IF:19.1)

12) Yaguang Zhang#, Jin Xu#, Ran Jia#, Chunyan Yi#, Wangpeng Gu, Pengcheng Liu, Xinran Dong, Hao Zhou, Bo Shang, Shipeng Cheng, Xiaoyu Sun, Jing Ye, Xuezhen Li, Jia Zhang, Zhiyang Ling, Liyan Ma, Bingbing Wu, Mei Zeng*, Wenhao Zhou*, Bing Sun*. Protective humoral immunity in SARS-CoV-2 infected pediatric patients. Cell Mol Immunol, 17, 768–770 (2020). (5-Year IF:19.1)

13) Yaguang Zhang#*; Xuezhen Li#; Zhongguang Luo#; Liyan Ma; Songling Zhu; Zhishuo Wang; Jing Wen; Shipeng Cheng; Wangpeng Gu; Qiaoshi Lian; Xinhao Zhao; Weiguo Fan; Zhiyang Ling; Jing Ye; Songguo Zheng; Dangsheng Li; Hongyan Wang; Jie Liu*; Bing Sun*. ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation. Proc Natl Acad Sci U S A, 2020, 117(6): 3083-3092. (5-Year IF:12.0)

部分参与贡献论文

1) Xiaoyu Sun#, Chunyan Yi#, Yuanfei Zhu#, Longfei Ding#, Shuai Xia#, Xingchen Chen#, Mu Liu, Chenjian Gu, Xiao Lu, Yadong Fu, Shuangfeng Chen, Tianlong Zhang, Yaguang Zhang, Zhuo Yang, Liyan Ma, Wangpeng Gu, Gaowei Hu, Shujuan Du, Renhong Yan, Weihui Fu, Songhua Yuan, Chenli Qiu, Chen Zhao, Xiaoyan Zhang, Yonghui He, Aidong Qu, Xu Zhou, Xiuling Li, Gary Wong, Qiang Deng, Qiang Zhou, Hongzhou Lu, Zhiyang Ling*, Jianping Ding*, Lu Lu*, Jianqing Xu*, Youhua Xie*, Bing Sun*. Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2. Nat Microbiol. 2022 Jul;7(7):1063-1074.

2) Chunyan Yi#, Xiaoyu Sun#, Yixiao Lin#, Chenjian Gu#, Longfei Ding, Xiao Lu, Zhuo Yang, Yaguang Zhang, Liyan Ma, Wangpeng Gu, Aidong Qu, Xu Zhou, Xiuling Li, Jianqing Xu, Zhiyang Ling*, Youhua Xie*, Hongzhou Lu*, Bing Sun*. Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants. Genome Med. 2021 Oct 14;13(1):164.

3) Yunfan Sun#, Liang Wu#*, Yu Zhong#, Kaiqian Zhou#, Yong Hou#, Zifei Wang, Zefan Zhang, Jiarui Xie, Chunqing Wang, Dandan Chen, Yaling Huang, Xiaochan Wei, Yinghong Shi, Zhikun Zhao, Yuehua Li, Ziwei Guo, Qichao Yu, Liqin Xu, Giacomo Volpe, Shuangjian Qiu, Jian Zhou, Carl Ward, Huichuan Sun, Ye Yin, Xun Xu, Xiangdong Wang, Miguel A Esteban, Huanming Yang, Jian Wang, Michael Dean, Yaguang Zhang, Shiping Liu*, Xinrong Yang*, Jia Fan*. Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma. Cell. 2021 Jan 21;184(2):404-421.e16.

4) Chunyan Yi#, Xiaoyu Sun#, Jing Ye#, Longfei Ding, Meiqin Liu, Zhuo Yang, Xiao Lu, Yaguang Zhang, Liyang Ma, Wangpeng Gu, Aidong Qu, Jianqing Xu, Zhengli Shi*, Zhiyang Ling#*, Bing Sun*. Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies. Cell Mol Immunol. 2020 Jun;17(6):621-630.

5) Weiguo Fan#, Tianhui Liu#, Wen Chen#, Seddik Hammad, Thomas Longerich, Ingrid Hausser, Yadong Fu, Nan Li, Yajing He, Cui Liu, Yaguang Zhang, Qiaoshi Lian, Xinhao Zhao, Chenghua Yan, Li Li, Chunyan Yi, Zhiyang Ling, Liyan Ma, Xinyan Zhao, Hufeng Xu, Ping Wang, Min Cong, Hong You, Zhihong Liu, Yan Wang, Jianfeng Chen, Dangsheng Li, Lijian Hui, Steven Dooley*, Jinlin Hou*, Jidong Jia*, Bing Sun*. ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice. Gastroenterology. 2019 Nov;157(5):1352-1367.e13.

6) Shanshan Yan, Yaguang Zhang, Bing Sun*. The function and potential drug targets of tumour-associated Tregs for cancer immunotherapy. Sci China Life Sci. 2019 Feb;62(2):179-186. (Review)

团队长期招聘

1. 博士后。

具有基础医学或者生物医学等领域相关专业博士学位；身心健康，品行端正，遵纪守法，勤奋踏实，有团队合作精神。具备较强的科研能力，能独立开展和组织科研工作；专业背景为免疫学、细胞生物学等优先；年龄一般不超过35周岁，取得博士学位5年内；以第一作者在最有学术影响力的国际期刊发表论文1篇或在本学科SCI期刊上发表论文2篇；熟练掌握常规的生物医学研究实验技能；良好的英语技能（听、说、读、写优秀）。支持和协助申请《西安交通大学“青年优秀科研人才支持计划”》

2. 实验技术员。

年龄一般不超过30周岁，具有医学或者生物医学领域相关专业，本科及以上学历，有细胞生物学、分子生物学、免疫学等专业背景；身心健康，品行端正，遵纪守法，勤奋踏实，有强烈的事业心、责任感与服务意识；诚信，有团队协作精神；掌握常规的生物医学研究实验技能，如免疫组化，细胞培养，蛋白和核酸提取，分子和蛋白检测，组学分析和数据处理、气质/液质联用技术等；有操作小鼠实验和流式细胞实验经验者优先考虑。

3. 招收全日制硕士和博士研究生（统考和推免）。